{
  "id": 406602,
  "title": "Impact of Different Protein structures on the Protein functioning",
  "url": "/competitions/cafa-5-protein-function-prediction/discussion/406602",
  "author_name": "",
  "post_date": "2023-05-03T01:05:59.119698800Z",
  "votes": 4,
  "comment_count": 2,
  "views": 0,
  "content": "<p>My understanding is that if the Protein sequence is same but the structures(Secondary, Tertiary, Quarternary) are different, then the function of the Protein changes. Do we have any information of these structure in the data? If yes, then do we have any information on which structure is the most important one to impact the protein functionig?<br>\n I am still going through EDA. So, I might have missed out. </p>",
  "messages": [
    {
      "id": "2243498",
      "postDate": "05/03/2023 01:05:59",
      "content": "<p>My understanding is that if the Protein sequence is same but the structures(Secondary, Tertiary, Quarternary) are different, then the function of the Protein changes. Do we have any information of these structure in the data? If yes, then do we have any information on which structure is the most important one to impact the protein functionig?<br>\n I am still going through EDA. So, I might have missed out. </p>",
      "rawMarkdown": "My understanding is that if the Protein sequence is same but the structures(Secondary, Tertiary, Quarternary) are different, then the function of the Protein changes. Do we have any information of these structure in the data? If yes, then do we have any information on which structure is the most important one to impact the protein functionig?\n I am still going through EDA. So, I might have missed out.",
      "votes": null
    },
    {
      "id": "2244839",
      "postDate": "05/03/2023 23:18:08",
      "content": "<p>Protein structures are dynamic, but that doesn't mean that they change dramatically. It is kind of like a torso moving while we breathe, or movements of the head as we look around. The overall shape of the person is the same even when moving our heads or expanding the lung cavity, and that's the case for most proteins as well.</p>\n<p>Now, there are proteins that have disordered regions that can move around quite a bit, and also some \"chameleon\" sequences that can dramatically change the overall protein shape. However, both groups are definitely in minority when it comes to protein structures.</p>\n<p>A short answer to your question is that for this competition you probably don't need to worry about alternative protein structures. </p>",
      "rawMarkdown": "Protein structures are dynamic, but that doesn't mean that they change dramatically. It is kind of like a torso moving while we breathe, or movements of the head as we look around. The overall shape of the person is the same even when moving our heads or expanding the lung cavity, and that's the case for most proteins as well.\n\nNow, there are proteins that have disordered regions that can move around quite a bit, and also some \"chameleon\" sequences that can dramatically change the overall protein shape. However, both groups are definitely in minority when it comes to protein structures.\n\nA short answer to your question is that for this competition you probably don't need to worry about alternative protein structures.",
      "votes": null
    },
    {
      "id": "2246130",
      "postDate": "05/04/2023 22:44:31",
      "content": "<p>Got it, Thank you for explaining.</p>",
      "rawMarkdown": "Got it, Thank you for explaining.",
      "votes": null
    }
  ],
  "comments": [
    {
      "id": 2244839,
      "author_name": "tilii7",
      "author_url": "",
      "post_date": "05/03/2023 23:18:08",
      "content": "<p>Protein structures are dynamic, but that doesn't mean that they change dramatically. It is kind of like a torso moving while we breathe, or movements of the head as we look around. The overall shape of the person is the same even when moving our heads or expanding the lung cavity, and that's the case for most proteins as well.</p>\n<p>Now, there are proteins that have disordered regions that can move around quite a bit, and also some \"chameleon\" sequences that can dramatically change the overall protein shape. However, both groups are definitely in minority when it comes to protein structures.</p>\n<p>A short answer to your question is that for this competition you probably don't need to worry about alternative protein structures. </p>",
      "votes": null,
      "replies": []
    },
    {
      "id": 2246130,
      "author_name": "niti95",
      "author_url": "",
      "post_date": "05/04/2023 22:44:31",
      "content": "<p>Got it, Thank you for explaining.</p>",
      "votes": null,
      "replies": []
    }
  ],
  "raw_markdown_by_id": {
    "2243498": "My understanding is that if the Protein sequence is same but the structures(Secondary, Tertiary, Quarternary) are different, then the function of the Protein changes. Do we have any information of these structure in the data? If yes, then do we have any information on which structure is the most important one to impact the protein functionig?\n I am still going through EDA. So, I might have missed out.",
    "2244839": "Protein structures are dynamic, but that doesn't mean that they change dramatically. It is kind of like a torso moving while we breathe, or movements of the head as we look around. The overall shape of the person is the same even when moving our heads or expanding the lung cavity, and that's the case for most proteins as well.\n\nNow, there are proteins that have disordered regions that can move around quite a bit, and also some \"chameleon\" sequences that can dramatically change the overall protein shape. However, both groups are definitely in minority when it comes to protein structures.\n\nA short answer to your question is that for this competition you probably don't need to worry about alternative protein structures.",
    "2246130": "Got it, Thank you for explaining."
  },
  "source": "meta"
}